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Literature summary for 3.4.21.76 extracted from

  • Yang, T.H.; St John, L.S.; Garber, H.R.; Kerros, C.; Ruisaard, K.E.; Clise-Dwyer, K.; Alatrash, G.; Ma, Q.; Molldrem, J.J.
    Membrane-associated proteinase 3 on granulocytes and acute myeloid leukemia inhibits T cell proliferation (2018), J. Immunol., 201, 1389-1399 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.76

Localization

Localization Comment Organism GeneOntology No. Textmining
azurophil granule
-
 Homo sapiens 42582
-
cell membrane
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P24158
-
-

Source Tissue

Source Tissue Comment Organism Textmining
granulocyte
-
 Homo sapiens
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marrow cell
-
 Homo sapiens
-
additional information proteinase 3 is expressed by myeloid cells and localized within azurophil granules, it is also expressed on the cellular membrane of polymorphonuclear neutrophils (PMN) Homo sapiens
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polymorphonuclear neutrophil
-
 Homo sapiens
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T-cell acute myeloid leukemia cell
-
 Homo sapiens
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T-lymphocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
membrane-associated proteinase 3
-
 Homo sapiens
mP3
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of proteinase 3 in chronic myeloid leukemia induces apoptosis of high-affinity PR1-specific T cells, leading to deletional tolerance and leukemia outgrowth Homo sapiens
physiological function effect of membrane proteinase 3-expressing polymorphonuclear neutrophils (PMN) and acute myeloid leukemia (AML) blasts on the proliferation of CD4 and CD8 T cells in vitro, overview. mP3-expressing PMN significantly inhibits autologous healthy donor T-cell proliferation but does not affect cytokine production in activated T-cells. This effect requires cell proximity and is abrogated by proteinase 3 blockade. This inhibition requires proteinase 3 enzyme activity. The suppression is not reversed by either the addition of catalase or the inhibition of arginase I. PMN inhibit T cell proliferation in a cell contact-dependent manner. In addition to proteinase 3 blockade, anti-low density lipoprotein receptor-related protein 1 (LRP1) Ab also restores T cells' capacity to proliferate. Dose-dependent inhibition of T-cell proliferation by mP3-expressing acute myeloid leukemia blasts Homo sapiens